Working hours:
Monday to Friday - 9.30 to 6.00 Saturday - 9.30 to 4.00
|
Test Parameter |
Specification |
Typical Result |
Test Method |
|
Identification (IR) |
Conforms to Reference Standard |
Conforms |
USP/EP |
|
Assay (Anhydrous Basis) |
98.5% - 101.5% |
99.8% |
HPLC |
|
Loss on Drying |
1.0% |
0.3% |
Thermo- gravimetric |
|
Residue on Ignition |
0.1% |
0.05% |
Gravimetric |
|
Related Substances (HPLC) |
|||
|
Any Individual Impurity |
0.5% |
<0.1% |
HPLC |
|
Total Impurities |
2.0% |
0.3% |
HPLC |
|
Total Plate Count |
1000 CFU/g |
<10 CFU/g |
Microbial Enumeration |
|
Heavy Metals (as Pb) |
10 ppm |
<5 ppm |
ICP-MS/AAS |
Packaging: 25 kg per fiber drum with double polyethylene liner."
Storage Conditions: Preserve in well-closed, light-resistant containers, in a cool, dry place."
Shelf Life/Expiry Date: Validity period under recommended storage
Vitamin B1's primary role is to act as a coenzyme (thiamine pyrophosphate) in converting carbohydrates from food into usable cellular energy (ATP). It is also essential for proper nervous system function and supports heart health.
Excellent sources include:
Whole Grains & Fortified Foods: Brown rice, oatmeal, fortified breakfast cereals, whole wheat bread.
Legumes: Black beans, lentils, soybeans.
Nuts & Seeds: Sunflower seeds, flaxseeds.
Animal Sources: Pork (especially lean cuts), trout, tuna.
Yeast: Nutritional yeast is a potent source.
Deficiency can lead to:
Early/Mild: Fatigue, irritability, reduced reflexes, muscle weakness.
Severe: Beriberi (with "wet" form affecting the heart and "dry" form affecting nerves) and Wernicke-Korsakoff syndrome (a serious brain disorder often linked to chronic alcoholism, causing confusion, vision issues, and memory loss).
Individuals with Alcohol Use Disorder: Alcohol severely impairs thiamine absorption and storage.
People with Certain Medical Conditions: Those with Crohn's disease, anorexia, or who have undergone bariatric surgery.
Older Adults: Due to potentially poor diet and decreased absorption.
People with Diets High in Refined Carbs/Sugar: These increase the body's demand for B1 for metabolism.
Vitamin B1 is considered very safe with a low risk of toxicity. It is water-soluble, so excess amounts are typically excreted in urine. There is no established Tolerable Upper Intake Level (UL) because no adverse effects from high oral intakes have been reliably reported. However, extremely high doses from supplements are unnecessary and not recommended.
Yes, thiamine is heat-sensitive and water-soluble. Boiling, especially in large amounts of water that is then discarded, can lead to significant losses. To preserve B1, use cooking methods like steaming, microwaving, or using minimal water.
Benfotiamine is a fat-soluble, synthetic derivative of thiamine. It has much higher bioavailability and is primarily used in therapeutic contexts, especially in Europe, for supporting nerve health in conditions like diabetic neuropathy.
Regular Thiamine (HCl or Mononitrate) is the standard, water-soluble form found in most foods and multivitamins.
Diagnosis: Based on clinical symptoms, dietary history, and often confirmed by measuring erythrocyte transketolase activity in the blood, which is a functional test for thiamine status.
Treatment: Involves high-dose thiamine supplements, initially often via injection in severe cases, followed by oral maintenance doses and dietary improvement.
Most healthy individuals who eat a balanced diet do not need a supplement. However, a supplement may be necessary and beneficial for the at-risk groups mentioned above (e.g., those with alcohol dependence, malabsorption issues, or poor dietary intake). Always consult a healthcare provider before starting any new supplement.
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